糖心logo入口

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CATEGORIES:College of Engineering,Graduate Studies,Thesis/Dissertations
DESCRIPTION:BMEBT MS Thesis Defense by Abid Neron Date: May 15, 2026 Time: 
 11 AM Location: TEX 219 Title: Investigation of the OCY454-12H Cell Line a
 s an In Vitro Model for Type 2 Diabetes Mellitus-Associated Bone Dysfuncti
 on Abstract: Type 2 diabetes mellitus (T2DM) is a globally prevalent metab
 olic disorder increasingly recognized for its detrimental effects on skele
 tal integrity. Patients with T2DM exhibit increased bone fragility, which 
 results in a heightened risk of bone traumas, yet the underlying mechanism
 s remain poorly understood. Chronic hyperglycemia and the production of ad
 vanced glycation end-products (AGEs) are thought to play a critical role i
 n skeletal deterioration by activating the receptor for advanced glycation
  end-products (RAGE) pathway, promoting inflammation and bone resorption. 
 Despite this association, the cellular responses of osteocytes to varying 
 glycemic conditions have not been fully characterized in vitro. This study
  investigates the OCY454-12H cell line, an osteocyte-like, murine-derived 
 conditionally immortalized model with enhanced SOST expression, as an in v
 itro model for T2DM-associated bone dysfunction. Cells were exposed to var
 ying glucose concentrations for 10 days to model hyperglycemic conditions.
  Then, gene and protein expression levels of key biomarkers, SOST and RAGE
 , were quantified using qPCR and ELISA analyses. Significant glucose-depen
 dent increases in gene and protein expression were identified, with 22 mM 
 and 34 mM glucose groups most closely matching biomarker profiles reported
  in T2DM-associated bone dysfunction in vivo. These findings provide preli
 minary support for the OCY454-12H cell line as a platform for investigatin
 g hyperglycemia-induced osteocyte dysfunction and establish candidate gluc
 ose concentrations for future in vitro T2DM bone models. Advisor: Dr. Lamy
 a Karim, Dept. of Bioengineering (lkarim@umassd.edu) Committee Members: Dr
 . Tracie Ferreira, Dept. of BioengineeringDr. Laura Hanzly, Dept. of Bioen
 gineering All BMEBT graduate students are encouraged to attend, and all in
 terested parties are invited.\nEvent page: /events/c
 ms/bmebt-ms-thesis-defense-by-abid-neron.php
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</script><p>BMEBT MS Thesis Defense by Abid
  Neron</p>\n<p>Date: May 15\, 2026</p>\n<p>Time: 11 AM</p>\n<p>Location: T
 EX 219</p>\n<p>Title: Investigation of the OCY454-12H Cell Line as an In V
 itro Model for Type 2 Diabetes Mellitus-Associated Bone Dysfunction</p>\n<
 p>Abstract: Type 2 diabetes mellitus (T2DM) is a globally prevalent metabo
 lic disorder increasingly recognized for its detrimental effects on skelet
 al integrity. Patients with T2DM exhibit increased bone fragility\, which 
 results in a heightened risk of bone traumas\, yet the underlying mechanis
 ms remain poorly understood. Chronic hyperglycemia and the production of a
 dvanced glycation end-products (AGEs) are thought to play a critical role 
 in skeletal deterioration by activating the receptor for advanced glycatio
 n end-products (RAGE) pathway\, promoting inflammation and bone resorption
 . Despite this association\, the cellular responses of osteocytes to varyi
 ng glycemic conditions have not been fully characterized in vitro. This st
 udy investigates the OCY454-12H cell line\, an osteocyte-like\, murine-der
 ived conditionally immortalized model with enhanced SOST expression\, as a
 n in vitro model for T2DM-associated bone dysfunction. Cells were exposed 
 to varying glucose concentrations for 10 days to model hyperglycemic condi
 tions. Then\, gene and protein expression levels of key biomarkers\, SOST 
 and RAGE\, were quantified using qPCR and ELISA analyses. Significant gluc
 ose-dependent increases in gene and protein expression were identified\, w
 ith 22 mM and 34 mM glucose groups most closely matching biomarker profile
 s reported in T2DM-associated bone dysfunction in vivo. These findings pro
 vide preliminary support for the OCY454-12H cell line as a platform for in
 vestigating hyperglycemia-induced osteocyte dysfunction and establish cand
 idate glucose concentrations for future in vitro T2DM bone models.</p>\n<p
 >Advisor: Dr. Lamya Karim\, Dept. of Bioengineering ()</p>\n<p>Committee Members: <br
  />Dr. Tracie Ferreira\, Dept. of Bioengineering<br />Dr. Laura Hanzly\, D
 ept. of Bioengineering</p>\n<p>All BMEBT graduate students are encouraged 
 to attend\, and all interested parties are invited.</p><p>Event page: <a h
 ref="/events/cms/bmebt-ms-thesis-defense-by-abid-ner
 on.php">/events/cms/bmebt-ms-thesis-defense-by-abid-
 neron.php</a></a></p></body></html>
DTSTAMP:20260425T100556
DTSTART;TZID=America/New_York:20260515T110000
DTEND;TZID=America/New_York:20260515T120000
LOCATION:TEX 219
SUMMARY;LANGUAGE=en-us:BMEBT MS Thesis Defense by Abid Neron
UID:2f098acdbdd5f1f0e9cbc0cf61111c0e@www.umassd.edu
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