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CATEGORIES:College of Engineering,Thesis/Dissertations
DESCRIPTION:Biomedical Engineering & Biotechnology BMEBT MS Thesis Defense 
 by Sean Crowley Date: June 11, 2026 Time: 12:30 PM Location: TEX 219 Title
 : Comparison of Ribose and Glucose for In Vitro Glycation of Human Cortica
 l Bone Abstract: Patients with diabetes are at a much higher risk of exper
 iencing bone fractures compared to non-diabetic populations. This happens 
 despite diabetics having relatively normal or high bone mineral density, c
 ausing questions as to why this occurs. Past research has shown that diabe
 tic bone tissue has a higher prevalence of non-enzymatic glycation, a spon
 taneous process where the aldehydes of sugars react with 蔚-amino groups o
 n proteins in the bone matrix to eventually form advanced glycation end-pr
 oducts (AGEs). AGEs alter cross-links within the matrix, which can lead to
  stiffer tissue and deteriorated mechanical properties. High AGE accumulat
 ion can occur over decades, which makes it a challenge to obtain represent
 ative data from diabetic patients or cadaveric bone tissue in order to stu
 dy these mechanisms. In vitro incubation simulations have been successfull
 y used to reflect the process of non-enzymatic glycation in bone tissue, w
 ith AGE accumulating in a matter of days/weeks. These simulations normally
  use ribose as the extracellular sugar source. Even though glucose is more
  physiologically relevant, it has little documentation in its usage in the
 se simulations. This project investigates the effectiveness and difference
 s in reactions of both ribose and glucose with human cortical bone. Bone s
 amples were incubated with control, ribose, and glucose solutions, and wer
 e then tested to measure key mechanical properties as well as AGE accumula
 tion. Differences in results are reported, analyzed, and discussed within 
 this thesis, providing more insight into the mechanisms of non-enzymatic g
 lycation鈥檚 effect on bone properties. Advisor: Dr. Lamya Karim, Dept. of
  Bioengineering (lkarim@umassd.edu) Committee Members: Dr. Tracie Ferreira
 , Dept. of Bioengineering Dr. Qinguo Fan, Dept. of Bioengineering All BMEB
 T graduate students are encouraged to attend, and all interested parties a
 re invited.\nEvent page: /events/cms/bmebt-ms-thesis
 -defense-by-sean-crowley.php
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</script><p>Biomedical Engineering & Biotec
 hnology</p>\n<p>BMEBT MS Thesis Defense by Sean Crowley</p>\n<p>Date: June
  11\, 2026</p>\n<p>Time: 12:30 PM</p>\n<p>Location: TEX 219</p>\n<p>Title:
  Comparison of Ribose and Glucose for In Vitro Glycation of Human Cortical
  Bone</p>\n<p>Abstract: Patients with diabetes are at a much higher risk o
 f experiencing bone fractures compared to non-diabetic populations. This h
 appens despite diabetics having relatively normal or high bone mineral den
 sity\, causing questions as to why this occurs. Past research has shown th
 at diabetic bone tissue has a higher prevalence of non-enzymatic glycation
 \, a spontaneous process where the aldehydes of sugars react with 蔚-amino
  groups on proteins in the bone matrix to eventually form advanced glycati
 on end-products (AGEs). AGEs alter cross-links within the matrix\, which c
 an lead to stiffer tissue and deteriorated mechanical properties. High AGE
  accumulation can occur over decades\, which makes it a challenge to obtai
 n representative data from diabetic patients or cadaveric bone tissue in o
 rder to study these mechanisms. In vitro incubation simulations have been 
 successfully used to reflect the process of non-enzymatic glycation in bon
 e tissue\, with AGE accumulating in a matter of days/weeks. These simulati
 ons normally use ribose as the extracellular sugar source. Even though glu
 cose is more physiologically relevant\, it has little documentation in its
  usage in these simulations. This project investigates the effectiveness a
 nd differences in reactions of both ribose and glucose with human cortical
  bone. Bone samples were incubated with control\, ribose\, and glucose sol
 utions\, and were then tested to measure key mechanical properties as well
  as AGE accumulation. Differences in results are reported\, analyzed\, and
  discussed within this thesis\, providing more insight into the mechanisms
  of non-enzymatic glycation鈥檚 effect on bone properties.</p>\n<p>Advisor
 : Dr. Lamya Karim\, Dept. of Bioengineering (lkarim@umassd.edu)</p>\n<p>Co
 mmittee Members:</p>\n<p>Dr. Tracie Ferreira\, Dept. of Bioengineering</p>
 \n<p>Dr. Qinguo Fan\, Dept. of Bioengineering</p>\n<p>All BMEBT graduate s
 tudents are encouraged to attend\, and all interested parties are invited.
 </p><p>Event page: <a href="/events/cms/bmebt-ms-the
 sis-defense-by-sean-crowley.php">/events/cms/bmebt-m
 s-thesis-defense-by-sean-crowley.php</a></a></p></body></html>
DTSTAMP:20260525T011621
DTSTART;TZID=America/New_York:20260611T123000
DTEND;TZID=America/New_York:20260611T133000
LOCATION:TEX 219
SUMMARY;LANGUAGE=en-us:BMEBT MS Thesis Defense by Sean Crowley
UID:6bffba0b08e845a77c9b5bec6db6a82b@www.umassd.edu
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